Ofd1 controls dorso-ventral patterning and axoneme elongation during embryonic brain development.
Oral-facial-digital type I syndrome (OFDI) is a human X-linked dominant-male-lethal developmental disorder caused by mutations in the OFD1 gene.Similar to other inherited disorders associated to ciliary dysfunction OFD type I patients display neurological abnormalities.We characterized the neuronal phenotype that results from Ofd1 inactivation in e